Deconvolution and Restoration of Optical Endomicroscopy Images

Optical endomicroscopy (OEM) is an emerging technology platform with preclinical and clinical imaging utility. Pulmonary OEM via multicore fibres has the potential to provide in vivo in situ molecular signatures of disease such as infection and inflammation. However, enhancing the quality of data acquired by this technique for better visualization and subsequent analysis remains a challenging problem. Cross coupling between fiber cores is one of the main reasons of poor detection performance (i.e., inflammation, bacteria, etc.). In this work, we address the problem of deconvolution and restoration of OEM data. We propose and compare four methods, three are based on the alternating direction method of multipliers (ADMM) and one is based on Markov chain Monte Carlo (MCMC) methods. Results on both synthetic and real datasets illustrate the effectiveness of the proposed methods.